The internal area of influence of the Puerto de Guaymas or Hinterland, by its ubication, the Puerto de Guaymas has the character of a regional port to which access by sea to international trade routes is done by the Pacific Ocean and the Gulf of Cortez.

The Influence zone which currently serves the port is represented by the states of Sonora, Baja California Sur, Chihuahua, Sinaloa and Arizona in the U.S.